Endocrine Abstracts

Introduction: Acromegaly is characterized by high cardiovascular morbidity and mortality. Oxidative stress and endothelial dysfunction are underlying mechanisms of atherosclerosis. The aim of this study was to evaluate the blood redox status and endothelial function by means of nitric oxide (NO) levels in patients with acromegaly.Description of methods/design: Total antioxidant capacity (TAC), catalase activity and glutathione concentration (GSH), as mea...

Introduction: The recent ADA and EASD algorithm for the treatment of type 2 DM suggests addition of basal insulin or GLP-1 agonist to pre-existing treatment when glycemic control is not achieved.Aim: Compare efficacy and safety of exenatide (E) versus insulin Glargine (G) added after metformin monotherapy.Patients and methodOur study was open labeled, non- randomized, retrospective and included 48 patients, 1...

Introduction: Antithyroid drugs (ATD) remain the first-line therapy in patients with Graves’ disease (GD), despite high relapse rate. The purpose of the present study was to identify predictors of long term remission of GD in patients who received ATD as primary treatment.Description of methods/design: We restrospectively identified patients with Graves’ disease initially treated with ATD between 1984 and 2011 and extracted relevant data from t...

Introduction: Fine Needle Aspiration Biopsy (FNA) is a method widely used in the assessment of thyroid nodules. The main aim of this 18-year retrospective study was the investigation of the diagnostic value of FNA in the approach of thyroid malignancy.Subjects and methods: patients underwent 1938 FNAs from 1987 to 2004 in the Department of Endocrinology, ‘Hippocration’ General Hospital, Thessaloniki, Greece. 178 of these patients subsequently u...

Introduction: High serum homocysteine (Hcy) has been associated with insulin resistance (IR) syndrome and cardiovascular risk, although controversy exists. Nonalcoholic fatty liver disease (NAFLD) is regarded as the hepatic component of IR syndrome, but data on Hcy are limited. The aim of this cross-sectional study was to evaluate serum Hcy levels in patients with NAFLD.Methods: Thirty-one consecutive patients (54±11years, 8 males) with biopsy-prove...